diabetes metabolic syndrome
Conditions
Interventions
High-fat meal without (CON) or with added protein: pea-protein (PP),
gluten-protein (GP) or their hydrolysates (PPH and GPH respectively)
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: male * central obesity: waist circumference >=94 cm plus any one of the following four factors: * raised triglyceride level: >=1.7 mmol/L; * reduced high-density lipoprotein (HDL) cholesterol: =130 mmHg or diastolic BP >=85 mmHg or use of blood pressure lowering medication * raised fasting plasma glucose >= 5.6 mmol/L Additional inclusion criteria: * age 45-65 years * body weight should be stable for at least 6 months * stable exercise habits during the last 6 months, and not participating in any vigorous exercise program
Exclusion criteria
Exclusion criteria: * (undiagnosed) diabetes - but not impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) as evaluated by an oral glucose tolerance test at screening (plasma glucose: fasting > 7.0 and/or 2-hours > 11.1 mmol/L) * High triglyceride levels (> 5 mmol/L) or high blood pressure (> 160/95 mmHg) at screening * Low haemoglobin level at screening (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| main study parameters include postprandial responses in metabolic factors (insulin, glucose, triglycerides), inflammation markers and endothelial function (tonography) . | — |
Secondary
| Measure | Time frame |
|---|---|
| secundary studie parameters are changes in satiety markers (GLP) and changes in oxidative stress as measured in PBMCs | — |
Countries
Netherlands
Outcome results
None listed