Effects of engine oil fumes on neurobiological outcome measures

Effects of engine oil fumes on neurobiological outcome measures - BRAINAIR

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34165

Enrollment

Registered

2011-03-03

Start date

2011-01-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

engine oil fumes

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Flight attendants with cognitive complaints as determined by Nederlands Centrum voor Beroepsziekten (NCvB), aged between 35 and 50 years (M/F). Control group: healthy volunteers, aged between 35 and 50 years, who have attended less than 1-2 flights lifetime (M/V).

Exclusion criteria

Exclusion criteria: A history of neuropsychiatric disease, alcohol abuse. Contraindications for MRI (e.g. osteosynthetic material, pacemaker, artificial cardiac valves); claustrophobia.

Design outcomes

Primary

Measure	Time frame
Differences between both groups in: NPO (cognition, depression and anxiety). MRI outcome: brain volume, neurometabolites (Cho/Cr, NAA/Cr), white matter integrity (FA), brain perfusion (CBF), and difference in brain activation during an executive functioning task measuring planning abilities (Tower of London) and a paired associates task measuring episodic memory.	—

Secondary

Measure	Time frame
N.a.	—

Countries

Netherlands

Outcome results