The Effect of Gaucher Disease on Bone Cells

The Effect of Gaucher Disease on Bone Cells - The Effect of Gaucher Disease on Bone Cells

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34135

Enrollment

Registered

2011-02-28

Start date

2011-04-18

Completion date

Unknown

Last updated

2024-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gaucher disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients 1. Men and women between the age of 18 and 65 years 2. Informed consent 3. Patient with a proven diagnosis of Gaucher disease 4. Stable (

Exclusion criteria

Exclusion criteria: Patients and healthy controls: 1. Documented inflammatory or malignant bowel disease 2. Previous bowel surgery, both small intestine and/or colon, with the exception of appendicular surgery. 3. Cholestatic disease defined by elevated values of AP or gammaGT > 2 x upper reference limit 4. Fever of unknown cause during the past 4 weeks prior to study 5. Co-morbidity influencing bone metabolism: Renal insufficiency (creatinin clearance

Design outcomes

Primary

Measure	Time frame
osteoblast proliferation, osteoblast differentiation, osteoclastogenesis, osteoclast function	—

Countries

Netherlands

Outcome results