Genetic influences on autonomic nervous system activity and the pro-inflammatory state: the moderating role of mental health status.

Genetic influences on autonomic nervous system activity and the pro-inflammatory state: the moderating role of mental health status. - Twin family research on mental and physical health

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34118

Enrollment

600

Registered

2010-09-09

Start date

2010-11-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiovascular disease depression

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Twin or sibling of twin, registered in the Netherlands Twin Registry (NTR), previous participation in NTR BioBank, 18-50 years of age, living in the Netherlands

Exclusion criteria

Exclusion criteria: Pregnancy, current heart disease, pacemaker or metal objects due to bone fracture

Design outcomes

Primary

Measure	Time frame
Autonomic Nervous System: - Heart rate, - Heart Rate Variability ( Total IBI Power, SDNN, RMSSD, HF-IBI power, LF-IBI power, VLF-IBI power, peak-valley RSA), Respiration Rate, - Systolic and Diastolic BP - Pre-ejection period (PEP) - Left ventricular ejection time (LVET) - Cardiac autonomic balance (CAB) - Cardiac autonomic regulation (Co-AR) Pro-inflammatory state: - TNFa, - IL-6, - soluble IL-6 receptor, - CRP, - Fibrinogen Mental health: - Spielberger Trait Anxiety Inventory - YASR anxious/depression subscale - EPQ neuroticism subscale - Rosenberg Self-esteem - Happiness Scale - Satisfaction with Life Covariates: - Sex and age - Socioeconomic status (educational attainment, current profession) - Regular leisure time exercise - Major stressful life events - Body Mass Index & Waist-Hip Ratio - Current smoking & alcohol use - Medication use (current) - Pittsburg Sleep Quality Inventory (PSQI) - Groningse Slaap Kwaliteit Lijst (GSKL) - POMS (Profile Of Mood States) * shortened version - Cortisol (Awakening levels + AUC)	—

Measure

Time frame

Autonomic Nervous System: - Heart rate, - Heart Rate Variability ( Total IBI Power, SDNN, RMSSD, HF-IBI power, LF-IBI power, VLF-IBI power, peak-valley RSA), Respiration Rate, - Systolic and Diastolic BP - Pre-ejection period (PEP) - Left ventricular ejection time (LVET) - Cardiac autonomic balance (CAB) - Cardiac autonomic regulation (Co-AR) Pro-inflammatory state: - TNFa, - IL-6, - soluble IL-6 receptor, - CRP, - Fibrinogen Mental health: - Spielberger Trait Anxiety Inventory - YASR anxious/depression subscale - EPQ neuroticism subscale - Rosenberg Self-esteem - Happiness Scale - Satisfaction with Life Covariates: - Sex and age - Socioeconomic status (educational attainment, current profession) - Regular leisure time exercise - Major stressful life events - Body Mass Index & Waist-Hip Ratio - Current smoking & alcohol use - Medication use (current) - Pittsburg Sleep Quality Inventory (PSQI) - Groningse Slaap Kwaliteit Lijst (GSKL) - POMS (Profile Of Mood States) * shortened version - Cortisol (Awakening levels + AUC)

—

Secondary

Measure	Time frame
None	—

Countries

Netherlands

Outcome results