hoog risico patienten en/of hoog risico chirurgie high risk surgery high risk patient
Conditions
Interventions
If despite volume expansion the StO2 will be below 80%, norepinephrine (initial
dose 0.03 ug/kg/min) and/or dobutamine infusion (initial dose of 2.5 ug/kg/min)
will be started and gradually increase
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: •Major elective surgery •Aged over 65 years with moderate functional limitation of one or more organ systems •ASA classification III or IV, i.e. severe cardiac, vascular, respiratory or metabolic illness resulting in severe functional limitation •Routine use of arterial and central venous lines •Planned postoperative stay on ICU or PACU
Exclusion criteria
Exclusion criteria: • Refusal of consent • acute myocardial ischemia prior to enrolment • patients receiving palliative treatment only • disseminated malignancy • patients unlikely to survive more than 6 hours • emergency surgery • transplantations • neurosurgical patients • patients undergoing extensive liver surgery requiring low CVP management
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary end point of the feasibility study will be a to evaluate the incidence of perioperative complications (organ dysfunction, SOFA score, troponin T, creatinin, CRP). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary end points include feasibility of the interventions. | — |
Countries
Netherlands
Outcome results
None listed