The Neurobiological Basis of Disengagement: A Mechanism Implicated in Visuospatial Attention.

The Neurobiological Basis of Disengagement: A Mechanism Implicated in Visuospatial Attention. - The Neurobiology of Disengagement

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON34082

Enrollment

Registered

2010-07-20

Start date

2011-03-18

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Geen aandoening

Interventions

Nicorette Freshmint 2mg will be used for manipulating (facilitating) the cholinergic system.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: participants must be male and between 18-40 years old.

Exclusion criteria

Exclusion criteria: - Hypersensitivity to nicotine or other substances in the chewing-gum - oral infection or pharyngitis - active oesophagitis - (history of) cardiovascular disease - liver failure / insufficiency - Kidney failure / insufficiency - Diabetes mellitus - Use of medication

Design outcomes

Primary

Measure	Time frame
Behavioural measures: In the VSC (Visual Spatial Cueing) paradigm: the validity effect in ms (RT valid cued target - RT invalid cued target). A larger validity effect reflects either more bias, or less disengagement. In the stop task paradigm, the time needed (in milliseconds) to abort a prepotent response: the Stop Signal Reaction Time (SSRT); SSRT reflects inhibition and related disengagement but is also dependent on bias. Neurophysiological (Event Related Potentials, task related brain activity) endparameters in the VSC: 1) Parietal cue Event Related Potential (ERP) components. These are the Anterior Directing Attention Negativity (ADAN) and the Late Directing Attention Positivity (LDAP). Both are related to bias. 2) P1 ERP (following a validly cued target); associated with bias. 3) Late Positive Deflection (LPD) ERP (following an invalidly cued target); associated with disengagement. Neurophysiological (ERP) endparameters in the stop task: 1) N2 ERP (following the onset of a stopsignal), associated with disengagement. 2) LPD ERP (following the onset of a stopsignal), associated with disengagement.	—

Measure

Time frame

Behavioural measures: In the VSC (Visual Spatial Cueing) paradigm: the validity effect in ms (RT valid cued target - RT invalid cued target). A larger validity effect reflects either more bias, or less disengagement. In the stop task paradigm, the time needed (in milliseconds) to abort a prepotent response: the Stop Signal Reaction Time (SSRT); SSRT reflects inhibition and related disengagement but is also dependent on bias. Neurophysiological (Event Related Potentials, task related brain activity) endparameters in the VSC: 1) Parietal cue Event Related Potential (ERP) components. These are the Anterior Directing Attention Negativity (ADAN) and the Late Directing Attention Positivity (LDAP). Both are related to bias. 2) P1 ERP (following a validly cued target); associated with bias. 3) Late Positive Deflection (LPD) ERP (following an invalidly cued target); associated with disengagement. Neurophysiological (ERP) endparameters in the stop task: 1) N2 ERP (following the onset of a stopsignal), associated with disengagement. 2) LPD ERP (following the onset of a stopsignal), associated with disengagement.

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Secondary

Measure	Time frame
Dependent variables are identical to the primary parameters. The independent variable is a subject variable: smoker/non-smoker. (See protocol for details).	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)