dysmorphophobia hair pulling disrder
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: BDD patients and TTM patients: - Physically healthy subjects - Male and female, aged between 18-65 years - Diagnosis of BDD by DSM -IV criteria, confirmed by the Structured Clinical Interview of DSM-IV - Able to provide written informed consent and to comply with all study procedures.;Inclusion criteria: Control group - Physically healthy subjects - Male and female, aged between 18-65 - Absence of psychiatric DSM-IV axis I disorders, confirmed by the Structured Clinical Interview of DSM-IV Axis Diagnoses (SCID) - Absence of psychiatric DSM-IV axis II disorders, confirmed by the Structured Clinical Interview of DSM-IV Axis Diagnoses (SCID) - Able to provide written informed consent and to comply with all study procedures.
Exclusion criteria
Exclusion criteria: Excusion criteria: BDD patients and TTM patients: - Comorbidity of DSM-IV axis I disorders. In case of depressive symptoms, the score on the Hamilton Depression Rating Scale (HDRS) should be less then 16 - Comorbidity of DSM-IV axis II disorders in cluster A or B ;Exclusion criteria: General - Currently participating in an investigational study, or having participated in such a study within 30 days of their enrollment. - Use of psychotropic medication within four weeks before the first test day. - Drug or alcohol-abuse over a period of three weeks prior to the experiment. More then 15 cigarettes and more then 6 cups of caffeine containing coffee, cola or tea. - A history of neurological illness or other medical problems potentially having central nervous system sequellae. - Pregnancy, breast feeding and use of inadequate anticonception. - Use of other medication potentially influencing cerebral blood flow. - Ongoing psychotherapy. Behavioral psychotherapy must be discontinued at least three months before the first test day. - Contraindications for MRI scan (claustrofobia, inclusion of metal components in the body, e.g. pacemaker)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study parameter is the total number of striatal D2 receptors. A ratio will be calculated of radio-activity counts in the ROIs (striatal activity) compared to the reference region (cortical activity). | — |
Secondary
| Measure | Time frame |
|---|---|
| no secundary study parameters | — |
Countries
Netherlands
Outcome results
None listed