THE PHARMACOKINETIC AND PHARMACODYNAMIC INTERACTION BETWEEN PROPOFOL AND KETAMINE WHEN GIVEN FOR SEDATION AFTER CARDIAC SURGERY IN THE INTENSIVE CARE UNIT.

THE PHARMACOKINETIC AND PHARMACODYNAMIC INTERACTION BETWEEN PROPOFOL AND KETAMINE WHEN GIVEN FOR SEDATION AFTER CARDIAC SURGERY IN THE INTENSIVE CARE UNIT. - Propofol - ketamine interaction after cardiosurgery in the ICU

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON34050

Enrollment

Registered

2010-07-22

Start date

2010-11-01

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sedativum op IC na cardiochirurgische ingreep eris geen sprake van een te bestuderen aandoening

Interventions

During study A, 21 ICU patients will be sedated using a target controlled infusion of propofol at one of 3 fixed target propofol concentrations in addition to a target controlled infusion of S(+) ke

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Scheduled for ventilation and sedation at the ICU post cardiac surgery. Aged 18-80 years. Being able to give written informed consent.

Exclusion criteria

Exclusion criteria: Unable to give written informed consent. Increased intracranial pressure Poor ventricular function Epilepsy Psychosis Glaucoma History of cerebrovascular incident 35).

Design outcomes

Primary

Measure	Time frame
• Ramsay score • BIS score • Cardiac Output (Vigileo) • Cardiac Index (Vigileo) • RRsys • RRdias • MAP • CVP • HR • SVV • SVR • Saturation	—

Secondary

Measure	Time frame
Concentration of propofol and ketamine from the several blood draws.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)