Efficacy of a novel experimental antibody in a humanized mouse model of psoriasis

Efficacy of a novel experimental antibody in a humanized mouse model of psoriasis - Monoclonal antibodies in psoriasis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON34037

Enrollment

Registered

2011-01-12

Start date

2011-02-14

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

flaking disease psoriasis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Psoriasis patients: Adults (m/f) with a mild form of psoriasis vulgaris (PASI score of maximal 6). Patients are allowed to use local corticosteroids or ointments to prevent dry skin (see Appendix 2).

Exclusion criteria

Exclusion criteria: Psoriasis patients: These patients have not received light therapy or another form of systemic treatment (methotrexate, cyclosporin A, anti-TNF treatments). Gender or age of the adults are not considered as exclusion criteria (see Appendix 2).

Design outcomes

Primary

Measure	Time frame
The effect of treatment on the psoriatic process is tested by histological and immuno-histochemical techniques in the transplanted biopsies. The main read-out is epidermal thickness.	—

Secondary

Measure	Time frame
Serum markers in blood of transplanted mice will be studied together with markers on cultured cells from psoriasis patients. Markers of inflammation in serum or RNA isolated from blood cells and in the skin.	—

Countries

Netherlands

Outcome results