malnutrition undernutrition
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - malignant tumour in the upper digestive and airway tract: larynx, pharynx or oral cavity - curative treatment with surgery and postoperative radiotherapy, or radiotherapy, or chemoradiation - age 18 year or above - caucasian race - good understanding of dutch language
Exclusion criteria
Exclusion criteria: - palliative treatment - tumor in other region than head and neck region (either secondary primary tumor or metastasis) - amputated arm(s)/leg(s) - oedema as a result of cardial failure, ascites, nefrological or hepatic dysfunction - orthopedic prosthesis (hip or knee) - pacemaker - dementia/mental dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome measurement is changes in body composition (fat mass and lean body mass), assessed by: - DEXA (dual energy x-ray absorptiometry). - anthropometerics: skinfold measurements (triceps, biceps, subscapula, supra-iliaca), upper arm (muscle) circumference - hand grip strength - bio-electrical impedance analysis (BIA) | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measurements are: - serum levels leptin, adiponectin, FT3, FT4, TSH, IGF-1, IGF-BP3, albumin, prealbumin, transferrin, total cholesterol, CRP, IL-1, IL-6, TNF-a and hemoglobine - presence of symptoms/complaints - performance score | — |
Countries
Netherlands
Outcome results
None listed