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Evaluation of intrarenal oxygenation in patients after receiving a kidney from non-heart-beating and living donors by BOLD MRI on a 3.0 T scanner 1 day after surgery.

Evaluation of intrarenal oxygenation in patients after receiving a kidney from non-heart-beating and living donors by BOLD MRI on a 3.0 T scanner 1 day after surgery. - Intrarenal oxygenation in kidney transplantation

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON33999
Enrollment
36
Registered
2009-03-09
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Transplantatie ischemia/reperfusion injury kidney transplantation

Interventions

None listed

Sponsors

Academisch Ziekenhuis Maastricht
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients receiving a kidney from a living donor Patients reveiving a kidney from a NHB donor Living donors Donor age > 18 years Able to give informed consent Written informed consent

Exclusion criteria

Exclusion criteria: Age 60 years

Design outcomes

Primary

MeasureTime frame
Hypoxia 1. Medullary and cortical oxygenation (R2*)—

Secondary

MeasureTime frame
Hypoxia 1. Medullary and cortical O2 consumption (after furosemide administration) 2. Medullary and cortical perfusion (after Gadovist administration) 3. Urine HIF-1a and carbonic anhydrase IX concentration Kidney function 1. Dialysis dependency after transplantation 2. Area under the curve for serum creatinine concentration over time (14 days) 3. Fractional excretion of sodium (14 days) Renal cellular injury 1. Examining biopsies according to protocol—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)