schizophrenia and psychosis
Conditions
Interventions
Participants will be asked to inhale THC and placebo in one session and to
subsequently undergo a PET scans. In addition they will be asked to undergo a
total of 1 MRI scan.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 18-50 years of age life-time use of cannabis without having experienced negative effects BMI between 18.5 and 27 diagnosis of schizophrenia according to DSM-IV (only patients) having given informed consent (written and orally)
Exclusion criteria
Exclusion criteria: head trauma severe renal or liver dysfunction alcohol use in excess of 5 units per day weekly use of illicit drugs (other than cannabis) pregnancy breast-feeding personal or family history of psychosis or use of antipsychotic medication (only valid for healthy participants who are no first degree relatives of patients with schizophrenia)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (i) Dopamine response after THC and placebo (ii) Psychotic experiences in response to THC and placebo as measured with i) computer-assisted tasks and ii) clinical interviewing | — |
Secondary
| Measure | Time frame |
|---|---|
| (i) genotype (on the basis of DNA analyses) | — |
Countries
Netherlands
Outcome results
None listed