psychosis proneness Schizotypy
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Psychosis proneness Participants will be selected from a random selection within the upper extreme of the distribution according to the CAPE scores (above the 75th percentile, high schizotypy group), and a random selection within 0.5 SD around the mean (control group).
Exclusion criteria
Exclusion criteria: Subjects with history of psychiatric or relevant neurologic disease will be excluded from the study. Further exclusion criteria will be based on the presence of MRI incompatible implants. For safety reasons we will also exclude female participants who may be pregnant. Subjects with claustrophobia, alcohol and/or drug abuse, or insufficient grasp of the Dutch language will also be excluded. To make sure subjects are only prone to psychosis and not clinically psychotic, the following questions will be asked to them: (1) Are you in treatment for a psychiatric disorder?, (2) Do you have any psychiatric problems? Should they answer positively to either one of these questions, they will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters will be the differences in brain activation between high an low psychosis prone adolescents while engaging in cognitive-emotional functions involved in insight into symptoms. In the present study, by using fMRI, we would like to investigate the activation of distinct brain areas engaged during self-evaluation, emotion regulation, affective and cognitive mentalizing, and reality monitoring, all being crucial cognitive-emotional processes involved in insight. fMRI has the best spatial resolution amongst the other non-invasive techniques which allow one to have the closest look at the neuronal activity available with imaging. Furthermore, current studies which have been investigating cognitive processes related to self-awareness and emotion regulation are mostly behavioral. Additionally, the few available studies on the use of fMRI paradigms has been indeed promising toward an effective delineation of the neural correlates subserving these functions by this technique. In light of this, the proposed study would be an innovative research that, besides elucidating the cognitive and neural basis of subclinical psychotic symptoms, will also inform our future studies of self-processing in relation to poor insight (illness awareness) in psychosis. | — |
Countries
Netherlands
Outcome results
None listed