atherosclerosis narrowing of the artery
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Selected for CEA based on (symptomatic or asymptomatic) carotid stenosis (>70%) * Participation in Athero-Express study * 18 years or older and of sound mind * Male or female
Exclusion criteria
Exclusion criteria: * Patients with a physical handicap (immobility) * Patients with no informed consent * Allergic reaction to gadolinium in the past * Impaired renal function (severe renal insufficiency, GFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of micro vascular micro infarcts in the perfusion area of the carotid artery associated with specific plaque characteristics. To visualize plaque characteristics that have been associated with micro-embolisms and post-operative stroke with high-resolution MRI (3 Tesla and 7 Tesla). Therefore we will mainly look at microvessels (neovasculature) and lipid rich plaques | — |
Secondary
| Measure | Time frame |
|---|---|
| To visualize all plaque characteristics identified on histology and compare them with the high-resolution MR images (3 Tesla and 7 Tesla). golden standard will be the histology Comparison of pre- and post operative MR scan aimed at the perfusionstate of the brain. (Evaluate whether the operation improved perfusion in the brain) and whether specitic components are related to the perfusion state/recovery of perfusion state. | — |
Countries
Netherlands
Outcome results
None listed