Cross-sectional cohort study to analyse the relation between advanced glycation end-products (AGEs) and diastolic function in patients with diabetes mellitus with and without chronic heart failure.

Cross-sectional cohort study to analyse the relation between advanced glycation end-products (AGEs) and diastolic function in patients with diabetes mellitus with and without chronic heart failure. - DIABAGES

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33946

Enrollment

200

Registered

2009-02-23

Start date

2009-01-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diastolic heart failure heart failure

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: General • Signed Informed consent • Age > 18 years;Diabetes patients with chronic heart failure • Type 2 DM according to ADA criteria • Stable CHF diagnosed according to ESC criteria • Duration of HF > 3 months • NYHA functional class II-IV ;Diabetes patients without chronic heart failure • Type 2 DM according to ADA criteria • No evidence of heart failure;Patients with chronic heart failure without DM type 2 • No type 2 DM (fasting glucose 1 month • NYHA functional class II-IV;Normal controls • No type 2 DM (fasting glucose

Exclusion criteria

Exclusion criteria: • Sustained/Accepted atrial fibrillation • Severe Valvular Disease • Pacemaker use (ICD allowed with backup pacing

Design outcomes

Primary

Measure	Time frame
diastolic function serum and plasma AGEs	—

Secondary

Measure	Time frame
NYHA-functional class 6MWT (6 Minutes Walk Test) Minnesota Living with Heart Failure questionnaire Arterial compliance using Pulse Wave Analysis (PWA)	—

Countries

Netherlands

Outcome results