caries preventie caries dental decay
Conditions
Interventions
All volunteers will rinse their mouth twice-daily in a randomised order with 1)
a mouthwash containing low molecular weight fraction of edible mushroom
Shiitake extract, 2) a placebo mouthwash or 3)
Sponsors
Vrije Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy males and females that would: * Be 18 years of age or older * Be in good general health as determined by the investigator based on a review of the medical history/update * Possess at least three posterior teeth (premolars/molars) in each quadrant (with no partial dentures, orthodontic banding or wires)
Exclusion criteria
Exclusion criteria: * Have not passed all inclusion criteria * Have used antibiotics less than three months prior the start of the study * Have untreated caries or periodontal disease * Have reduced stimulated salivary flow (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of organic acids in plaque and microbial composition of plaque before and after each test period | — |
Secondary
| Measure | Time frame |
|---|---|
| Amount of dental plaque before and after each test period | — |
Countries
Netherlands
Outcome results
None listed