Which role do genetic polymorphisms play in relation to respiratory tract infections in children with Down syndrome ?

Which role do genetic polymorphisms play in relation to respiratory tract infections in children with Down syndrome ? - TLR polymorphisms in Down syndrome

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33938

Enrollment

600

Registered

2009-03-09

Start date

2009-09-14

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Down Syndrome innate immunity

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: 1.written informed consent from both parents or legal guardian(s) 2. age 0 until 18 years 3. sex: male and female 4. Down syndrome: trisomy 21

Exclusion criteria

Exclusion criteria: 1. not meeting inclusion criteria 2. Down syndrome: translocation or mozaicism

Design outcomes

Primary

Measure	Time frame
To investigate the genetic variation in TLRs and related genes in children with DS compared to a cohort of healthy controls.	—

Secondary

Measure	Time frame
To investigate if a relationship exists between certain genetic polymorphisms in TLR genes and an increased susceptibility to respiratory tract infections within the group children with DS.	—

Countries

Netherlands

Outcome results