Detection of expiratory flow limitation in COPD patients using within-breath forced oscillation technique during CPAP.

Detection of expiratory flow limitation in COPD patients using within-breath forced oscillation technique during CPAP. - FOT and CPAP

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON33930

Enrollment

Registered

2009-04-27

Start date

2009-05-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic bronchitis chronic obstructive pulmonary disease

Interventions

CPAP at different levels of presure (0, 4, 6, 8,10 cmH2O)

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Presenting to the outpatient clinic Age 50-80 years Diagnosed with COPD according to the standard criteria Gold Stage II or IV COPD Current or ex-smokers (at least 10 PY) Stable disease (No current exacerbation or exacerbation during the 4 weeks previous to the inclusion)

Exclusion criteria

Exclusion criteria: History of exacerbation of COPD in the preceding month Upper airway obstruction Allergic Asthma OSAS (obstructive sleep apnea syndrome) Extreme obesity (BMI>30) Pulmonary disease other than COPD Clinically manifest cardiac disease (for example clinically relevant congestive heart failure, unstable angina pectoris)

Design outcomes

Primary

Measure	Time frame
deltaXrs (cmH20.s/L) at 8 Hz (mid inspiratory minus mid expiratory Xrs) at increasing levels of PEEP	—

Secondary

Measure	Time frame
Negative swing inintrapleural pressure at the beginning of the inspiration measured with an esophageal balloon Variation in bloodpressure during inspiration and exspiration spirometry: IC (L) Xrs-8, 12,16,20,24 (cmH20.s/L) Rrs-8,12,16,20,24 (cmH20.s/L)	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)