COPD
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Diagnosis of COPD, both male and female, age-range from 50 to 70 years, no respiratory tract infection or exacerbation of the disease for at least 4 weeks before the study, capable to provide informed consent, presence of other non-gastro-intestinal related, non-cardiovascular and non-renal chronic diseases are allowed in case the clinical status is stable for at least 4 weeks before the study;
Exclusion criteria
Exclusion criteria: External oxygen supplementation at rest; investigator's uncertainty about the willingness or ability of the patient to comply with the protocol requirements; participation in any other studies involving investigational or marketed products concomitantly or within two weeks prior to entry into the study; any kind of gastro-intestinal complains or gastrointestinal disease; use of NSAID (ibuprofen, acetylsalicic acid, naproxen, meloxicam, diclofenac); subjects who are still smoking as smoking is known to increase the intestinal permeability.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biochemical parameters: markers of intestinal permeability in plasma (intestinal fatty acid binding protein (IFABP), ileal lipid-binding protein (ILBP), claudine) and urine (sugars) | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma markers of systemic inflammation interleukine 6 (IL-6), tumor necrosis factor-a (TNF-a), TNF soluble receptors 55 en 75, C-reactive protein (CRP), lipoprotein binding protein (LBP) and chemotactic cytokine ligand 18 (CCL-18). | — |
Countries
Netherlands
Outcome results
None listed