The effect of N-acetylcysteine and ascorbic acid on pulmonary arterial pressure and ventilation during normoxia, hypoxia and hyperoxia and total oxidant capacity.

The effect of N-acetylcysteine and ascorbic acid on pulmonary arterial pressure and ventilation during normoxia, hypoxia and hyperoxia and total oxidant capacity. - PAPOX

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON33919

Enrollment

Registered

2009-07-15

Start date

2010-02-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute mountain sickness COPD

Interventions

arterial line, venous line hyperoxia hypoxia

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: That the volunteer is healthy

Exclusion criteria

Exclusion criteria: Exclusion criteria are: • Obesity (BMI > 30) • Presence of medical disease: heart-, lung-, liver-, kidney- and lung disease; diabetes • Presence of psychiatric disease • History of chronic alcohol or drug use • Possibility of pregnancy • Lactation

Design outcomes

Primary

Measure	Time frame
pulmonal arterial pressure total oxidant capacity The ventilation will be analyzed on-line and is visible on-screen using custom made software (ACQ and RESREG developed by Erik Olofsen and Erik Kruyt, respectively). The breathing data will be collected on disc on a breath-to-breath basis for further analysis.zie protocol pagina 6 data steering	—

Secondary

Measure	Time frame
none	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)