manic depressive disorder
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Study A+B (longitudinal): participation at baseline;Study A+B+C+D (cross-sectional) New bipolar twin pairs 1) Part of a monozygotic or dizygotic twin pair 2) At least one twin has a diagnoses (life time) of Bipolar Disorder I or Bipolar Disorder II (DSM-IV criteria) 3) No history of drug or alcohol dependency (DSM-IV criteria) for the last half year 4) No history of Cognitive Disorder (DSM-IV criteria) 5) No history of serious neurological illness 6) No severe medical illness 7) Age between 18 and 60 years;New healthy control twin pairs 1) Part of a monozygotic or dizygotic twin pair 2) No history of axis I psychiatric disorder (DSM-IV criteria), on the basis of a SCID interview (Modules A-G) 3) No history of axis II personality disorder (DSM-IV criteria), on the basis of SIDP-V 4) No first degree relative with a history of specific axis I psychiatric disorder (DSM-IV criteria), on the basis of a FIGS interview 5) No history of drug or alcohol dependency (DSM-IV criteria) for the last half year 6) No history of serious neurological illness 7) No severe medical illness 8) Age between 18 and 60 years;Siblings 1) full sibling of an included twin pair 2) No history of axis I psychiatric disorder (DSM-IV criteria), on the basis of a SCID interview (Modules A-G) 3) No history of axis II personality disorder (DSM-IV criteria), on the basis of SIDP-V 4) No history of drug or alcohol dependency (DSM-IV criteria) for the last half year 5) No history of serious neurological illness 6) No severe medical illness 7) Age between 18 and 60 years
Exclusion criteria
Exclusion criteria: Did not give written informed consent 2) Ferrous objects in or around the body (e.g. braces, glasses, pacemaker, metal fragments) 3) Drug or alcohol abuse over a period of six months prior to the experiment 4) History of closed-head injury 5) History of neurological illness or endocrinological dysfunction 6) Claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study A: Change in brain volume (sMRI) or gray/white matter density (Voxelbased morphometry) Study B: Change in immunology parameters Study C: Fractional anisotropy and magnetisation transfer ratio Study D: Genotype and gene expression data All studies: Baseline values or parameters which might intervene with the main study parameter (age, gender, years of education, symptoms, level of functioning, medication intake, life events) | — |
Countries
Netherlands
Outcome results
None listed