A clinical study to investigate the molecular effects of remote ischemic preconditioning in the myocardium of CABG patients with or without diabetes mellitus

A clinical study to investigate the molecular effects of remote ischemic preconditioning in the myocardium of CABG patients with or without diabetes mellitus - RIPC-CABG

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON33897

Enrollment

Registered

2009-05-18

Start date

2009-04-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary artery bypass grafting

Interventions

The remote ischemic preconditioning protocol (RIPC) exist of 3* 5 minutes of limb ischemia, induced by blood pressure cuff inflation of the upper arm. The first group will undergo this regimen after

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: >18 years, elective CABG surgery (with or without aortic valve surgery), written informed consent.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Main study parameters are expression of signalling pathway proteins, detected by molecular analysis from myocardial probes taken before and after RIPC protocols during CABG surgery. ( PKC-*, p38MAPK, ERK and HSP27).	—

Secondary

Measure	Time frame
Ee will investigate standard hemodynamic parameters obtained during standard cardiac surgery.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)