Intra-stomal and sublingual spectroscopy in septic and non-septic Intensive Care patients; effect of Nitroglycerine, Phenylephrine and Norepinephrine.

Intra-stomal and sublingual spectroscopy in septic and non-septic Intensive Care patients; effect of Nitroglycerine, Phenylephrine and Norepinephrine. - NIRS in intestinal stoma's and sublingual of intensive care patients.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33896

Enrollment

Registered

2009-04-10

Start date

2009-08-14

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intestinal ischaemia or lack-of-oxygen

Interventions

Introduction NIRS and SDF probe/sensor in stoma. "Passive Leg raising". Optimalisation filling status with colloids with "Fluid Challenge". Application of NTG, PE and NA.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Intensive care patients with an intestinal stoma. Septic versus non-septic patients. Both ventilated and spontaneously breathing patients are included.

Exclusion criteria

Exclusion criteria: Non-compliance of patient or relative. Dehiscence or serious oedema of the stoma. Serious haemorrhagic diathesis; platelet count 3.0. Haemodynamic instability; mean arterial pressure (MAP) 100 mmHg or > 20 % baseline. Patients with anuria. Fractures or luxation of the legs/hips. Symptomatic myocardial ischaemia. Nitroglycerine infusion for therapeutic indications (myocardial ischaemia). Serious laesions or infections of the mouth or tongue. Ileostoma*s are relatively contraindicated for NIRS cannulation. Patiens with marked clinical signs of intraabdominal hypertension

Design outcomes

Primary

Measure	Time frame
Base-line NIRS data in stoma and sublingually. NIRS data in stoma and sublingually after "Passive leg raising"; "fluid challenge"; NTG, PE and NA. Difference in septic and non-septic patients. Relation NIRS data and systemic haemodynamic parameters. Base line NIRS data in stoma and sublingually on day 3.	—

Secondary

Measure	Time frame
Not relevant.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)