immune mediated chronic diseases
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: RA patients with comorbidity 1.Fulfilling the ACR classification criteria for RA 2.Age > 65 years 3.No treatment with DMARD (Disease Modifying Antirheumatic Drugs) 4.Presence of co-morbidity;Healthy Controls 1.Have no chronic disease 2.Age > 65 years;RA patients without comorbidity 1.Fulfilling the ACR classification criteria for RA 2.Age > 65 years 3.No treatment with DMARD (Disease Modifying Antirheumatic Drugs) 4.No co-morbidity at start of the study;For OA patients 1.Fulfilling the ACR classification criteria for OA 2.Age >65 years 3.No co-morbidity at start of the study
Exclusion criteria
Exclusion criteria: For all groups (RA, OA and HC) 1.No informed consent 2.Severe anaemia defined as a Hb of less than 6.0 gr/l
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| First, is there a relation between multi-morbidity and a certain IRP/ microRNA profile and the GFI. | — |
Secondary
| Measure | Time frame |
|---|---|
| What changes in miRNA/ IRP are instrumental for the development of multi-morbidity? Such mechanistic insight could be useful to help or better define the IRP and could be a potential lead for therapeutic intervention. | — |
Countries
Netherlands
Outcome results
None listed