indigestion Upper abdominal complaints
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 18-65 years old Recurrent bothersome postprandial fullness, early satiation and/or epigastric pain At least 2 days per week for 3 months or more
Exclusion criteria
Exclusion criteria: Esophagitis Barrett's esophagus Peptic ulcer disease Prior gastrointestinal surgery Pregnancy Drug- or alcohol abuse Use of Aspirin in combination with Clopidogrel
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Differences in plasma and duodenal mucosal concentrations of apoA-IV and/or CCK between FD patients and healthy controls. Relationship between plasma and duodenal mucosal concentrations of apoA-IV and/or CCK upon duodenal lipid load and sensitivity to gastric distension and/or gastric emptying rate of FD patients. | — |
Primary
| Measure | Time frame |
|---|---|
| Differences in duodenal mRNA expression of genes, involved in the chylomicron-apoA-IV-CCK pathway, between FD patients and healthy controls. Relationship between duodenal mRNA expression of genes, involved in the chylomicron-apoA-IV-CCK pathway, upon duodenal lipid load and sensitivity to gastric distension and/or gastric emptying rate of FD patients. | — |
Countries
Netherlands
Outcome results
None listed