Metabolic effects of Deep Brain Stimulation in patients with Obsessive Compulsive Disorder.

Metabolic effects of Deep Brain Stimulation in patients with Obsessive Compulsive Disorder. - Metabolic effects of DBS in OCD.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33826

Enrollment

Registered

2009-02-06

Start date

2008-11-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive Compulsive Disorder (OCD)

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Subjects have signed informed consent. - Fulfilling in- and exclusion criteria according METC protocol number 07/330.

Exclusion criteria

Exclusion criteria: - Use of psychotropic drugs - Use of drugs of abuse - Pregnancy - Use of medication known to interfere with glucose or lipid metabolism. - Diabetes mellitus type 2 or impaired fasting glucose. - Primary lipid disorder. - Performance of vigorous exercise. - Renal insufficiency or elevated liver enzymes (>2.5x above reference range).

Design outcomes

Primary

Measure	Time frame
Plasma ACTH and cortisol. Cortisol in 24-h urine. Hepatic glucose production. Resting Energy expenditure (REE). Plasma lipids.	—

Secondary

Measure	Time frame
Alterations in cerebral perfusion (fMRI activity) Dopaminergic changes (SPECT D2 receptor binding). OCD symptom severity (YBOCS) and neuropsychological performance.	—

Countries

Netherlands

Outcome results