Obsessive Compulsive Disorder
Conditions
Interventions
Intervention: Half of the subjects will be randomly assigned to the placebo
condition and the other half will be randomly Subjects will be randomized to
treatment with either placebo, or single fixe
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - All patients meet the DSM-IV criteria for OCD - Y-Bocs score: * 18 if obsessions and compulsions; * 12 if only obsessions or compulsions - Male and female, aged between 18-70 years - Female patients of childbearing potential must have a negative pregnancy test and use reliable method of contraception. - Written informed consent - Eligible for exposure therapy
Exclusion criteria
Exclusion criteria: - Presence of any of the following DSM IV conditions: * Major depression (HDRS * 15) * Bipolar Disorder * Schizophrenia or any other psychotic disorder * Tic disorder * Substance related disorder during the past 6 months * Epilepsy or any structural CNS disorder of stroke within the last year;- Presence of primary or co-morbid personality disorder - Evidence of clinically significant and unstable cardiovascular, gastrointestinal, pulmonary, Renal, hepatic, endocrine or haematological disorders, glaucoma, myocardial infarction within de past year or micturition abnormalities. - Currently taking benzodiazepines - Patients at risk for suicide - Multiple serious drug allergies of known allergy for DCS - Inability to speak Dutch or English
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in Yale Brown Obsessive Compulsive Scale (Y-BOCS), time of onset of change on the Y-BOCS and time of administering DCS (directly pre- or post ERP). | — |
Secondary
| Measure | Time frame |
|---|---|
| VLGT : Verbal Learning and Memory Test WCST: Wisconsin Card Sorting Test TOL: Tower of London ET: Extinction Task CGI: Clinical Global Impression scale BABS: Brown Assessment of Belief Scale HDRS: Hamilton Depression Rating Scale HARS: Hamilton Anxiety Rating Scale SDS: Sheehan Disability Scales WHOQOL World Health Organization Quality of Life FSEC Fawcett side effects checklist Tic-P: Trimbos/iMTA questionnaire for Costs associated with Psychiatric Illness | — |
Countries
Netherlands
Outcome results
None listed