The effect of pre-versus postdilution and pore size on the clearance of mid size mocules.

The effect of pre-versus postdilution and pore size on the clearance of mid size mocules. - Clearance of mid size molecules with hemofiltration.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON33818

Enrollment

Registered

2009-03-30

Start date

2009-04-18

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

shock after cardiac arrest

Interventions

Hemofiltration with one of the earlier mentioned filters in 1 of the 3 modi (A, B, C)

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with shock after cardiac arrest, treated with hypothermia

Exclusion criteria

Exclusion criteria: no CVVH available contra-indication nadroparin

Design outcomes

Primary

Measure	Time frame
As a marker for the clearance of smallmolecules, the concentration of creatinin, urea and ADMA will be measured. As a marker for the clearance of the midmolecules, the concentrations of β2-microglobuline en Interleukine-6 will be measured. The concentrations will be measured in the arterial blood, postfilter blood and in the ultrafiltrate. We will measure the hematocrit in the bloodsamples. Primary endpoint Effectivity of the clearance of midmolecules, 15 minutes and 6 hours after start HVHF, expressed as: o Sieving coefficient o Concentration filtrate* filtrateflow	—

Measure

Time frame

As a marker for the clearance of smallmolecules, the concentration of creatinin, urea and ADMA will be measured. As a marker for the clearance of the midmolecules, the concentrations of β2-microglobuline en Interleukine-6 will be measured. The concentrations will be measured in the arterial blood, postfilter blood and in the ultrafiltrate. We will measure the hematocrit in the bloodsamples. Primary endpoint Effectivity of the clearance of midmolecules, 15 minutes and 6 hours after start HVHF, expressed as: o Sieving coefficient o Concentration filtrate* filtrateflow

—

Secondary

Measure	Time frame
Secundary endpoints · Effectivity of the clearance of midmolecules, 12 hours after start HVHF · Hemodynamics · Metabolic control · Other organfailure	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)