lung transplantation obesity
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All - Age>18 years - Lung transplantation >1year ago - Underlying disease state COPD or lung fibrosis - Able to undergo the study related assessments - Written informed consent Overweight/obese - Weight gain >10% since lung transplantation - Actual BMI>25 kg/m2 Normal weight - BMI 20-25 kg/m2 - Weight gain
Exclusion criteria
Exclusion criteria: - not able to walk independently - symptoms of rejection of the lung - recipients who just started a diet or changed there eating habits - Other underlying extra-pulmonary disease state that may interfere with the study outcome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body composition: Body mass index and fat-free mass Weight and fat-free mass will be measured by a Bioelectrical Impedance Analysis (bodystat 1500). The high correlation coefficient (r = 0.974), small bias and standard estimation of error of a Bioelectrical Impedance Analysis, makes it able to predict fat-free mass in pre- and post transplant patients. Daily physical activity, performance based Daily physical activity was assessed on a performance basis by the Digiwalker SW-200 (Yamax; Tokyo, Japan). This pedometer has proved to accurately detect steps taken, as an indication of volume of daily physical activity. It has also shown evidence of reliability and convergent and discriminative validity. In this study patients are instructed to wear the pedometer during ten days (until going to bed), and to record the number of steps per day. The number of minutes that they are swimming, doing fitness or cycling will be reported in a diary and will be converted into steps. Steps/day including the converted steps will be expressed as step equivalents. The last seven out of ten daily-records will be used for further processing. Daily physical activity, questionnaire based Daily physical activity was assessed in self-reported fashion with the Short QUestionnaire to ASsess Health-enhancing physical activity (SQUASH). This questionnaire is designed to give an indication of the habitual activity level, and has shown to be a fairly reliable and reasonably valid questionnaire (r = 0.36-0.74). It was expressed in MET/min (MET: ratio of exercise metabolic rate to resting metabolic rate) and total minutes a week. Food intake Food intake will be estimated by a dietitian using an extensive food anamnesis. Resting Metabolic Rate Resting metabolic rate (RMR) will be measured using the ventilated-hood technique. Criteria for a valid RMR are: a minimum of 15 minutes of steady state, the participants should not have eaten food 4 hours before the measurement, tes | — |
Secondary
| Measure | Time frame |
|---|---|
| Fatigue Fatigue based on daily activities in household, body care and social activities will be measured with the Dutch Exertion Fatigue Scale (DEFS). The DEFS contains nine questions, which have to answered on a five-point score ranging from 0 (no) to 4 (yes). A low score on the DEFS represents a low score on fatigue of daily activities (reliability: Cronbach*s alpha 0.91). Lower body strength Lower body strength is assessed using the sit-to-stand test. Lower body strength plays an important role in every-day-activities. This test involves counting the number of times, within 30 seconds, that the patient can come to a full stand from a seated position without using his arms. The 30-second sit-to-stand test has been shown to be reliable (test-retest correlation r = 0.80) and has been validated against the gold standard measure for lower-body strength, the leg-press test. According to Rikli and Jones, intraclass reliability is r = 0.89 (test-retest) and criterion validity related to leg press is r = 0.77 (test-retest). | — |
Countries
Netherlands
Outcome results
None listed