multiple sclerosis small fibre neuropathy
Conditions
Interventions
None listed
Sponsors
Orbis Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria - age: 18 years and older - clinical definite MS according to the revised McDonald criteria. - Brain MRI fulfilling the revised McDonald criteria. - a clinical stable condition. A clinical stable condition is defined as: a) a clinical state without any new significant symptoms and/or signs as declared by the patient to the best of his/her knowledge over 3 months prior to the study or b) No clear objective changes at neurological examination by the researcher when compared with recorded findings over three month before study entry (if available) c) No methylprednisolone treatment within 3 months before study entry - written informed consent - patients should be ambulant (Expanded Disability Status Scale (EDSS) score of
Exclusion criteria
Exclusion criteria: - patients not meeting the inclusion criteria - use ofmedication that would interfere with ANS assessment, or use of medication that is known to possibly cause peripheral neuropathy - Other illnesses that might cause autonomic impairment (e.g., parkinson(ism), peripheral neuropathy, diabetes mellitus, alcohol abuse [arbitrarily defined as daily consumption of 5 IU or more], renal dysfunction, systemic illnesses)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary analysis will consider the difference in IENFD between MS patients with symptoms and without symptoms of ANS dysfunction, as well as compared to healthy participants. | — |
Secondary
| Measure | Time frame |
|---|---|
| In secondary analysis the results of the IENFD will be related to the other outcome measures and clinical data. | — |
Countries
Netherlands
Outcome results
None listed