Brain metabolic changes during awake and asleep craniotomy measured by cortical microdialysis

Brain metabolic changes during awake and asleep craniotomy measured by cortical microdialysis - AWAKE study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33779

Enrollment

Registered

2009-03-09

Start date

2009-05-22

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Metabolism

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Indication for awake craniotomy (asleep-awake-asleep-procedure) or asleep craniotomy Age 18-80 years Informed consent

Exclusion criteria

Exclusion criteria: Diabetes mellitus Anemia (Hb

Design outcomes

Primary

Measure	Time frame
Changes in brain metabolites (glucose, glycerol, lactate, pyruvate, glutamate) Correlation between depth of anesthesia and brain metabolite changes	—

Secondary

Measure	Time frame
Difference in concentrations of metabolites between radiologically normal tissue and abnormal brain tissue. Brain propofol concentration in the three stages (anesthesia-awake-anesthesia) Blood concentration of metabolites and propofol over time	—

Countries

Netherlands

Outcome results