The role of innate immunity and regulatory T cells in the development of immune tolerance in early life.

The role of innate immunity and regulatory T cells in the development of immune tolerance in early life. - The development of immunological tolerance in early life

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33767

Enrollment

120

Registered

2009-05-19

Start date

2011-06-23

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

allergy

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: - antanatal diagnosed birthdefect such as schizis, duodenal atresia or orthopedic problems - uncomplicated pregnancy and delivery - birth planned in UMCU/WKZ - a term delivery - availability of cordblood - one or more times surgery in the first year of life

Exclusion criteria

Exclusion criteria: Complications during pregnancy (HELPP, infection) Use of immune modulating medication during pregnancy Smoking during pregnancy Perinatal complications - Prematurity (

Design outcomes

Primary

Measure	Time frame
Development in time of number, phenotype and function of several subsets of mononuclear cells with special attention for T regulatory cells. Levels and effect of immune modulating factors such as adenosine, PGE2 and innate stimuli on the function of immune cells over time.	—

Countries

Netherlands

Outcome results