Atherosclerosis vascular abnormalities
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Cases: - a cardiac, cerebral or peripheral vascular disease before the age of 40 - a positive family history for cardiovascular disease, defined as a first degree family member with a cardiovascular event before the age of 55 for men and 60 for women. Furthermore, they should be between the age of 36 and 56 years old. Controls: -Controls will be defined as healthy in case they have no cardiovascular history, such as no cardiac, cerebrovascular or peripheral artery disease and no complaints of angina, claudication or TIA and no family history for cardiovascular disease. Furthermore, they should be between the age of 36 and 56 years old.
Exclusion criteria
Exclusion criteria: Cases: - a positive history for hypertension or diabetes mellitus - pregnancy or lactating women - subjects below the age of 18 - unable to give informed consent Controls: Diseases mentioned at the inclusioncriteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in glycocalyx volume, before and after sublingual nitroglycerine administration between the different study groups | — |
Secondary
| Measure | Time frame |
|---|---|
| To compair the glycocalyx volume of the different study groups we measure this year, with last year's measurements. | — |
Countries
Netherlands
Outcome results
None listed