Characterization of veterinary and community acquired MRSA: determinants, transmissibility and virulence

Characterization of veterinary and community acquired MRSA: determinants, transmissibility and virulence - VET.CAM study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33751

Enrollment

1250

Registered

2007-12-04

Start date

2008-05-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hospital bacteria MRSA

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Index-cases of any age are eligible - Index-cases have at least one household member (only applicable for VET study) - Household members of any age are eligible

Exclusion criteria

Exclusion criteria: - Living on a farm with pigs or veal calves - Professional contact with pigs or veal calves by the household members - Treatment for colonization of MRSA in the last 3 months of the index-case or any of the household members - Living in a nursing home or other healthcare facility - Persons who are no patients, for example MRSA positive health care workers of the participating hospital - Persons living abroad (only appicable for CAM study)

Design outcomes

Primary

Measure	Time frame
The difference in transmissibility of NT-MRSA and CA-MRSA compared to T-MRSA. This is primarily determined by the prevalence of secondary cases among household members (secondary attack rate). A secondary case is defined as a household member that carries the same molecular type of MRSA as the index-case. The prevalence of transmission is calculated by dividing the total number of secondary cases by the total number of susceptible household members. Furthermore, the determinants of NT-MRSA and CA-MRSA carriage will be defined using a questionnaire. The prevalence of these determinants will be compared with HA-MRSA carriage and non-MRSA carriage. To determine the virulence of NT-MRSA and CA-MRSA the occurrence of infections caused by these MRSAs are compared. Also the occurrence of medical events in general and the use of antimicrobial agents is measured. The burden of disaese will be measured using four short self-administrated questionnaires. Adjustment for factors that may affect the occurrence of disease will be applied using regression analysis.	—

Measure

Time frame

The difference in transmissibility of NT-MRSA and CA-MRSA compared to T-MRSA. This is primarily determined by the prevalence of secondary cases among household members (secondary attack rate). A secondary case is defined as a household member that carries the same molecular type of MRSA as the index-case. The prevalence of transmission is calculated by dividing the total number of secondary cases by the total number of susceptible household members. Furthermore, the determinants of NT-MRSA and CA-MRSA carriage will be defined using a questionnaire. The prevalence of these determinants will be compared with HA-MRSA carriage and non-MRSA carriage. To determine the virulence of NT-MRSA and CA-MRSA the occurrence of infections caused by these MRSAs are compared. Also the occurrence of medical events in general and the use of antimicrobial agents is measured. The burden of disaese will be measured using four short self-administrated questionnaires. Adjustment for factors that may affect the occurrence of disease will be applied using regression analysis.

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Countries

Netherlands

Outcome results