diabetes type 2 diabetes mellitus
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Male sex • Age 18-65 years • BMI 25-35 kg/m2 • Sedentary • Stable dietary habits • Healthy • Not wanting to be informed about a conincedence finding.
Exclusion criteria
Exclusion criteria: • Current use of medication that is known to interfere with the results of the study. • Consuming more than 20 g of alcohol per day (± 2 units) • Serum-γ-glutamyltranspeptidase level > 70 IU/L • A history of cardiovascular disease like congestive heart failure or acute myocardial infarction • Plasma triacylglycerol > 4.5 mmol/L • Familial hypercholesterolemia • A history of liver disease • Unstable body weight (weight gain or loss > 3 kg in the past three months) • Abuse of drugs • Participation in another biomedical study within 1 month prior to the screening visit • Impossible or difficult venipuncture during screening • a fasting glucose above 7.0 mmol/L • a contraindication to MRI scanning. These contraindications include patients with the following devices: o Central nervous system aneurysm clips; o Implanted neural stimulator; o Implanted cardiac pacemaker or defibrillator; o Cochlear implant; o Ocular foreign body (e.g. metal shavings); o Insulin pump; o Metal shrapnel or bullet; o Or metal containing corpora aliena in the eye of brains
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameter is the difference in insulin sensitivity after a switch from a low-fat diet to a high-fat diet compared to the control group, which stays on a low-fat diet. | — |
Secondary
| Measure | Time frame |
|---|---|
| As secondary endpoints differences in lipid accumulation in heart liver and muscle, cardiac function, the time-course of lipid accumulation and the relationship between the tissue parameter lipid accumulation and the functional outcome parameter insulin resistance are considered. | — |
Countries
Netherlands
Outcome results
None listed