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The contribution of L-glutamine to L-citrulline and L-arginine synthesis, when L-alanyl-L-glutamine is supplied in an enteral or parenteral dose of 0,5 g/kg/day, in surgical patients

The contribution of L-glutamine to L-citrulline and L-arginine synthesis, when L-alanyl-L-glutamine is supplied in an enteral or parenteral dose of 0,5 g/kg/day, in surgical patients - Dipetide study 0,5 g/kg/day, surgical patients

Status
Unknown
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON33726
Enrollment
16
Registered
2009-11-02
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

upper abdominal surgery

Interventions

Group A (case: n=6): from the day before surgery and start tracer protocol until closure of the tracer protocol: 0.042g/kg/h alanyl-glutamine IV. Group B (case: n=6): from the day before surgery and

Sponsors

heelkunde
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Scheduled for upper gastrointestinal surgery (>2h surgery) Age between 35 and 70 y BMI

Exclusion criteria

Exclusion criteria: Liver failure Kidney failure Pregnancy Corticosteroids intake

Design outcomes

Primary

MeasureTime frame
The effect of the supplementation of glutamine on the metabolism of glutamine, citrulline and arginine, as well as the conversions of glutamine into citrulline and citrulline into arginine at organ and whole body level in surgical patients.—

Secondary

MeasureTime frame
Rate of appearance of phenylalanine (Phe) and the conversion of Phe into tyrosine (Tyr) will be used to calculate protein breakdown and synthesis.—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)