Image validation of laryngeal and hypopharyngeal cancer with histopathology for radiotherapy.

Image validation of laryngeal and hypopharyngeal cancer with histopathology for radiotherapy. - volume and localisation validation of laryngeal cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33702

Enrollment

Registered

2010-02-09

Start date

2010-05-28

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

larygeal cancer larynx carcinoma

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients of the above population scheduled for total laryngectomy. Informed consent

Exclusion criteria

Exclusion criteria: Patients with indications for primary radiotherapy. Patients with contraindications for surgery. Patients who meet exclusion criteria for MRI at 1.5 T as defined in the protocols of the radiology department. Patients with contraindication for CT contrast administration as defined in the protocols of the radiology department. Patients with insulin dependent diabetes mellitus. no informed consent.

Design outcomes

Primary

Measure	Time frame
The accuracy of the different image modalities to measure the tumour volume and outline as determined by comparison with histopathology as reference standard.	—

Secondary

Measure	Time frame
· assessment of microscopic invasion of the tumour in the surrounding tissue by histopathology. · determination of the interobserver variation for tumour delineation using the different image modalities. · feasibility of diffusion weighted imaging for laryngeal and hypopharyngeal cancer. · development of a clinical imaging protocol for gross tumour volume (GTV) and clinical tumour volume (CTV) delineation.	—

Measure

Time frame

· assessment of microscopic invasion of the tumour in the surrounding tissue by histopathology. · determination of the interobserver variation for tumour delineation using the different image modalities. · feasibility of diffusion weighted imaging for laryngeal and hypopharyngeal cancer. · development of a clinical imaging protocol for gross tumour volume (GTV) and clinical tumour volume (CTV) delineation.

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Countries

Netherlands

Outcome results