Functional neural networks in dementia; a longitudinal MEG study

Functional neural networks in dementia; a longitudinal MEG study - Funtional neural networks in dementia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33698

Enrollment

Registered

2008-12-08

Start date

2008-05-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer's disease dementia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: For patients: o Age between 18 and 85 o Minimal MMSE score of 18 o Recently diagnosed with *mild to moderate* Alzheimer*s disease or Frontotemporal dementia o Written informed consent For healthy controls: o Age between 18 and 85 o Written toestemming

Exclusion criteria

Exclusion criteria: For both patients and healthy controls: o Other neurodegenerative or cerebrovascular disease o Psychiatric disease or symptoms o Insufficient mastery of the Dutch language o Inability to communicate adequately.

Design outcomes

Primary

Measure	Time frame
Measures of functional connectivity; the synchronization likelihood and phase lag index (these are quantitative variables derived by a mathematical procedure using the original MEG signal).	—

Secondary

Measure	Time frame
Main network variables (described by graph theory applied to functional connectivity measures of MEG recordings) between patients and controls; the cluster coefficient (measure of local network structure) and the path length (measure of global network structure) MMSE score and outcomes of other neurological tests.	—

Countries

Netherlands

Outcome results