Obesity and asthma: effect of bariatric surgery on lung function, inflammation and quality of life.

Obesity and asthma: effect of bariatric surgery on lung function, inflammation and quality of life. - Interaction mechanisms in obesity and asthma

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33646

Enrollment

100

Registered

2009-06-30

Start date

2009-09-28

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

adiposity overweight

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age > 18 and 35 kg/m2. Approval for 1 year follow-up visits

Exclusion criteria

Exclusion criteria: Smoking > 10 sig/d or > 10 pack years (PY) COPD or other pulmonary pathology apart from asthma. Pregnancy Exacerbation in 4 weeks prior to screening Use of oral steroids Psychological instability

Design outcomes

Primary

Measure	Time frame
The group size is powered on the expected change in FEV1/FVC ratio before and after bariatric surgery. Based on our pilot study and the results in the literature we assume that in obese patients with asthma the FEV1/FVC ratio increases from 72% to 75% (SD ± 6).	—

Secondary

Measure	Time frame
Secondary endpoints are symptom score, FeNO levels and inflammatory parameters (see study design).	—

Countries

Netherlands

Outcome results