Dopaminergic neurotransmission and cognitive deterioration in velocardiofacial syndrome

Dopaminergic neurotransmission and cognitive deterioration in velocardiofacial syndrome - Dementia in VCFS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33641

Enrollment

Registered

2009-09-14

Start date

2009-12-18

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

deletion 22q11.2 DiGeorge syndrome

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Deletion 22q11.2 Group 1: premorbid IQ > 70 . At this moment IQ

Exclusion criteria

Exclusion criteria: Pregnancy Age 65 Somatic problems which mimic dementia, such as hypothroid. Psychiatric disorders with dementia like symptoms, such as depressive disorder and dementia's of other origine

Design outcomes

Primary

Measure	Time frame
Blood and urine samples will be collected to determine dopaminergic markers. Also we will obtain blood samples to determine erythrocyte COMT activity, proline levels in serum and COMT and PRODH polymorphisms. Behavioural and psychiatric parameters will be obtained through several questionnaires.	—

Secondary

Measure	Time frame
Medication status wil be added.	—

Countries

Netherlands

Outcome results