posttraumtic stress disorder psychotrauma
Conditions
Interventions
Treatment with prazosin or placebo for 8 weeks.
Sponsors
Militaire Geestelijke Gezondheidszorg
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age between 18 - 65 Veterans, active military personnel, refugees, or civilians with psychotrauma Subjects have to meet DSM-IV criteria for PTSD, as measured by SCID, with a CAPS score of > 50 PSQI scores of > 5
Exclusion criteria
Exclusion criteria: Substance or alcohol abuse/ dependence within the past six months Major systemic or neurological diseases Orthostatic hypotension before treatment History of micturition syncope History of allergic reaction to prazosin Use of psychotropic medication with apha 1 antagonizing properties Use of antihypertensive agents Start psychotherapy in the 6 weeks proceeding the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) A decrease in number of awakenings after treatment, as measured with PSG. 2) Subjective sleep quality using self reported questionnaires (sleep calendar, Pittsburgh Sleep Quality Index). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Changes of other PSG parameters after treatment (wake after sleep onset (WASO), sleep latency (SL), and total sleep time (TST), percentage rapid eye movement (REM) sleep, percentage non REM (NREM) 2, percentage NREM 3+ 4, delta-activity during NREM 3 + 4, mean heart rate during each sleep stage): 2) Correlation between improvement on subjective reports and the change in number of awakenings. | — |
Countries
Netherlands
Outcome results
None listed