essential hypertension high blood pressure
Conditions
Interventions
None listed
Sponsors
Interne Geneeskunde
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Men or women between 18 and 60 years of age at time of enrolment - Essential hypertension diagnosed before the age of 50 years. - At least 3 first-degree relatives of whom at least 1 should have hypertension and at least one from a different generation, willing to participate in the study. - Written informed consent
Exclusion criteria
Exclusion criteria: - Any known form of secondary hypertension, - Any known previous clinical complications of hypertension (angina, myocardial infarction, stroke, TIA, peripheral artery disease) at any time - known renal disease, including GFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To analyse genetic and genomic factors involved in the pathogenesis of hypertension. To analyse genetic, genomic and proteomic factors involved in changes in microalbuminuria. To analyse genetic, genomic and proteomic factors involved in changes in cardiac and large artery structure and function. | — |
Secondary
| Measure | Time frame |
|---|---|
| To analyse the proteomic factors involves in the pathogenesis of hypertension. To explore the role of oxidative stress and microinflammation in the pathogenesis of hypertension. To analyse genetic, genomic and proteomic factors associated with renal phenotypes in hypertensive subjects: elevated urinary albumin excretion (microalbuminuria, proteinuria) salt-sensitivity, reduced GFR, and end-stage renal disease. To analyse genetic, genomic and proteomic factors associated with presence or development of heart dysfunction and failure in hypertensive patients. | — |
Countries
Netherlands
Outcome results
None listed