hallucinations psychosis
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Physically healthy subjects, evaluated by medical history, physical examination and screening laboratory tests Experiences hallucinations with a frequency of at least once a week. Total SPQ score lower than 25 No diagnosis on axis I or II based on DSM -IV criteria, confirmed by the CASH and the SCID II interview. Age between 18-60
Exclusion criteria
Exclusion criteria: Use of psychotropic medication within four weeks before the scanning Drug or alcohol-abuse over a period of three weeks prior to the experiment. More then 15 cigarettes and more then 6 cups of caffeine containing coffee, cola or tea. A history of neurological illness or other medical problems potentially having central nervous system sequellae. Pregnancy, breast feeding and use of inadequate anti-conception. Use of other medication potentially influencing cerebral blood flow. Claustrophobia Exposure to radioactivity leading to yearly cumulative dose of 10 mSv or more Metal objects in or around the body (braces, pacemaker, metal fragments); Exposure to radioactivity leading to a yearly cumulative dose of 10 mSv or more.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 18F-Dopa influx rate constants (Ki) in subjects* striatal brain regions | — |
Secondary
| Measure | Time frame |
|---|---|
| 18F-Dopa influx rate constants (Ki) in other brain regions | — |
Countries
Netherlands
Outcome results
None listed