obesitas/hypertensie/glucose en lipiden metabolisme metabolic syndrome
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: pre-menopausal Caucasian women scheduled for Roux-en-Y gastric bypass surgery
Exclusion criteria
Exclusion criteria: any chronical medical condition except for glucose intolerance, hypertension and secondary dyslipidemia use of medication which interferes with dopamine metabolism clinically overt atherosclerotic events claustrophobia and unremovable metal objects tobacco use (i.e. smokers) malignant or uncontrolled hypertension (blood pressure >200/120 mmHg or blood pressure >180/110 mmHg with 1 or more drugs, or >160/100 with 2 or more drugs) unwilling or unable to provide informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - hypothalamic dopamine receptor binding capacity - insulin sensitivity - inflammatory changes in adipose tissue and liver | — |
Secondary
| Measure | Time frame |
|---|---|
| - bloodpressure and sympathetic activity - hypothalamic activity (measured with functional MRI) - phenotypical differences (adipose tissue distribution, plasma parameters) | — |
Countries
Netherlands
Outcome results
None listed