Microcirculatory changes during cardiac surgery: The effects of different modalities of cardiopulmonary bypass

Microcirculatory changes during cardiac surgery: The effects of different modalities of cardiopulmonary bypass - PULSATILE study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33586

Enrollment

Registered

2009-03-03

Start date

2009-07-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary stenosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients undergoing CABG surgery Age 18-85 years Informed consent

Exclusion criteria

Exclusion criteria: Re-operations Emergency operation Patients with insulin-dependent diabetes mellitus Patients with Body Mass Index (BMI) over 30 kg/m2

Design outcomes

Primary

Measure	Time frame
Change in microcirculatory perfusion, sublingual erythrocyte velocity, capillary diameter and capillary density.	—

Secondary

Measure	Time frame
Blood samples (in total 50 ml): creatinine, CK-MB, lactate, pH, HCO3-, nitrite/nitrate, prostacyclin, angiotensin II, IL-6, IL-10, TNF-alpha, free hemoglobin. Urine output, fluid balance, hemodynamic variables, left ventricle function, venous saturation, need for intra-aortic balloon pump, need for inotropic medication, ventilation time. Preoperative: demographic variables, left-ventricle function, serum creatinine, Euroscore (cardiac operative risk evaluation). Intraoperative: number of anastomoses, bypass-time, cross-clamp time, pump flow during CPB, temperature during CPB, MAP during CPB, energy equivalent pressure during CPB. Microcirculation measurement during ICU admission.	—

Measure

Time frame

Blood samples (in total 50 ml): creatinine, CK-MB, lactate, pH, HCO3-, nitrite/nitrate, prostacyclin, angiotensin II, IL-6, IL-10, TNF-alpha, free hemoglobin. Urine output, fluid balance, hemodynamic variables, left ventricle function, venous saturation, need for intra-aortic balloon pump, need for inotropic medication, ventilation time. Preoperative: demographic variables, left-ventricle function, serum creatinine, Euroscore (cardiac operative risk evaluation). Intraoperative: number of anastomoses, bypass-time, cross-clamp time, pump flow during CPB, temperature during CPB, MAP during CPB, energy equivalent pressure during CPB. Microcirculation measurement during ICU admission.

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Countries

Netherlands

Outcome results