Chronic heart failure
Conditions
Interventions
12 week physiotherapist guided exercise program
Sponsors
Onze Lieve Vrouwe Gasthuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria p 10 * Symptomatic systolic heart failure (documented clinical signs and symptoms of heart failure) documented for more than 3 months. * Left ventricular ejection fraction (EF) less than 40% estimated by 2D echocardiography. * New York Heart Association (NYHA) class: II and III. * Age between 18- 80 years * Clinically stable with regard to symptoms and optimal medical therapy for more than 2 weeks prior to inclusion.
Exclusion criteria
Exclusion criteria: exclusion criteria p 11 * Orthopedic, peripheral vascular or neurological disease limiting the ability to exercise * Documented exercise-induced ischemia * Documented exercise-induced ventricular tachycardia * Poorly controlled cardiac arrhythmias * Significant chronic pulmonary disease limiting the ability to exercise * Uncontrolled hypertension * Abnormal blood pressure response to exercise testing (systolic blood pressure >250 mmHg or diastolic blood pressure >120 mmHg.) Or blood pressure drop of > 20mmHg during baseline exercise test. * Major anemia * Aortic valve stenose * Co morbidity that contraindicate exercise * Terminal disease * Patients who can*t speak/understand or read the Dutch language
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of the functional capacity and to determine the prolonged effects of this intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundairy endpoints are: Serum levels of NT-proBNP serum levels of CRP Quality of live (assessed with MLHFQ) Glycocalyx thickness measured with SDF. Left ventricular ejection fraction | — |
Countries
Netherlands
Outcome results
None listed