A pilot study to characterize T cell responses in young children after influenza infection

A pilot study to characterize T cell responses in young children after influenza infection - T cell responses in children after influenza infection

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33577

Enrollment

125

Registered

2008-04-01

Start date

2008-05-15

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

influenza

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Index population: children hospitalized at Wilhelmina Children*s Hospital, Spaarneziekenhuis, St. Antonius Ziekenhuis, and Diakonessenhuis with influenza infection. Control Group: children hospitalized at Wilhelmina Children*s Hospital without influenza infection. Adults: adults employed at RIVM/NVI without influenza infection.

Exclusion criteria

Exclusion criteria: Index population: prematurity (gestational age

Design outcomes

Primary

Measure	Time frame
Height of the cellular immune response after stimulation of the white blood cells with influenza virus in vitro. The response will be characterized based on; influenza-specific cytokine induction, number of influenza-specific T cells, T cell activation and functional status.	—

Secondary

Measure	Time frame
Humoral immune response	—

Countries

Netherlands

Outcome results