Geen aandoening
Conditions
Interventions
Clonidine results in less noradrenaline turnover and in effect inhibits the
noradrenergic system.
Mecamylamine is a nicotinic acetylcholine receptor antagonist and hence,
inhibits the cholinergic sy
Sponsors
Universiteit Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Passing the physical/medical evaluation (in which cardiovascular functioning and blood pressure is evaluated) is a prerequisite.
Exclusion criteria
Exclusion criteria: Diagnosis of psychopathology. Current drug use Low blood pressure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Behavioural measures In the VSC paradigm: the validity effect in ms (RT valid cued target - RT invalid cued target). A larger validity effect reflects either more bias, or less disengagement. In the stop task paradigm: the stop signal reaction time (SSRT); SSRT reflects inhibition and related disengagement. Neurophysiological (ERP) endparameters in the VSC: 1) Parietal cue ERP components (ADAN + LDAP), related to bias. 2) P1 valid cued target ERP, related to bias. 3) LPD invalidly cued target ERP, related to disengagement. Neurophysiological (ERP) endparameters in the stop task: 1) N2 stop signal ERP, related to disengagement. 2) LPD stop signal ERP, related to disengagement. | — |
Countries
Netherlands
Outcome results
None listed