elevated blood pressure Hypertensie
Conditions
Interventions
Intra-arterial infusion of bevacizumab
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-50years old 2. Male 3. Results of serum glucose, lipids and creatinine should be within the laboratory's reference ranges. 4. Subject is able and willing to sign the Informed Consent Form prior to screening evaluations.
Exclusion criteria
Exclusion criteria: 1. Documented history of sensitivity/idiosyncrasy to medicinal products or excipients. 2. History of or current abuse of drugs, alcohol or solvents. 3. History of malignant disease. 4. First degree relatives with a history of cancer before the age of 50 5. Current use of medication. 6. Clinical evidence of cardiac or pulmonary disease 7. Hypertension ( systole >140mmHG, diastole >90mmHg) 8. Diabetes mellitus 9. Smoking 10. Any clinically relevant abnormality on ECG. 11. Inability to understand the nature and extent of the trial and the procedures required.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The fore-arm vasomotor response to administered bevacizumab, expressed as percentage change in forerarm blood flow ratio ( flow infused arm flow control arm form baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between VEGF concentrations in plasma and the vasoconstrictive response to bevacizumab | — |
Countries
Netherlands
Outcome results
None listed