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Early detection and monitoring of articular cartilage damage following knee trauma

Early detection and monitoring of articular cartilage damage following knee trauma - Detection of cartilage damage

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON33493
Enrollment
10
Registered
2009-09-29
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

focal cartilage lesion Osteoarthritis

Interventions

None listed

Sponsors

Universitair Medisch Centrum Utrecht
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age > 18y Recent kneetrauma (

Exclusion criteria

Exclusion criteria: Not trauma related knee effusion or haemarthrosis. Patients with an abnormal kidney function. Patients with a known anaphylactic reaction to Gadolinium or related substances.

Design outcomes

Primary

MeasureTime frame
Primary endpoint will be the development of an articular cartilage lesion. We will relate the changes in intraarticular parameters (defined as the dGEMRIC value and synovial fluid cytokine concentration) to the eventual development of an articular cartilage lesion (as determined with conventional MRI).—

Secondary

MeasureTime frame
Secondary endpoint parameters will be the relation between cytokine concentration (determined from synovial fluid) and cartilage quality (determined from the dGEMRIC values) and the relation between the clinical questionnaire scores on the one hand and cytokine concentrations and dGEMRIC values on the other hand.—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)